El losartán pertenece al grupo de los inhibidores de los receptores de angiotensina II, fármacos muy utilizados en el momento actual para el tratamiento de la. Queratodermia palmoplantar epidermolítica asociada a pelo lanoso, syndrome de Ehlers Danlos y miocardiopatía dilatada. Gaceta Dermatológica Ecuatoriana. Dermatol. peru. ; 13 (2): – HIPERQUERATOSIS PALMOPLANTAR Y ENFERMEDAD PERIODONTAL: SÍNDROME DE PAPILLON – LEFÉVRE – A.

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Multiple periodontal abscesses, pathologic migration and moderate to intense mobility affecting all the teeth were seen. Severe periodontal destruction is a typical radiographic finding in PLS patients 5. Subscriber If you already have your login data, please click here.

Carrillo aM. Bacterial studies of plaque at the site of the lesion in PLS showed a flora similar to that of periodontitis and was composed basically of virulent Gram-negative anaerobic pathogens such as Porphyromonas gingivalis, Prevotella intermedia and Actinomyces actinomycetemcomitans 5, 9. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. The clinical presentation, differential diagnosis, therapeutic and periodontal management of an 8-year old male child diagnosed with this syndrome is discussed.

Acroqueratosis Paraneoplásica (Síndrome de Bazex)

There was a complete regression of exfoliative erythroderma and palmoplantar hyperkeratosis after 28 and 90 days, respectively. We performed three skin biopsies scalp, upper right eyelid and right arm. In the present case, the diagnosis of PLS was made primarily based on the clinical, radiological and dermatological features besides analysis of laboratory tests.

HIV patients usually have superficial mycoses in many stages of the disease. Pratchyapruit WO, Kullavanijaya P.


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Body and facial keratosis pilaris are additional features which appear in the following years. Key words palmoplantar keratoderma, differential diagnosis, palmoplantar keratoderma, connexins, chronic regional endemic hydroarsenicis.

Synovectomy has been shown to alleviate the inflammation associated with destructive arthritis but may lead to loss in the range of the joint motion. Exfoliative erythroderma and palmoplantar hyperkeratosis associated with Majocchi’s granuloma by Trichophyton tonsurans in a patient with AIDS.

Genetic counseling Transmission appears to be autosomal dominant. The dermatologist prescribed hiperaueratosis 20 mg orally daily for the initial 3 months and then 10 mg orally per day for the next two months.

However, there is little evidence of antibiotic therapy having an effect on the prognosis of the dentition as no controlled trials have been hiperueratosis out. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Papillon-Lefevre syndrome treated with acitretin.

From Monday to Friday from 9 a. In general, the mutated genes codify for proteins named connexins, which are directly related to the cellular differentiation known as gap junction. The importance of early diagnosis of PLS-associated periodontitis and use of appropriate treatment methods should be recognized. For all other comments, please send your remarks via contact us. Intraoral examination showed the presence of the following permanent teeth Federation Dentaire Internationale 11, 12, 16, 21, 22, 31, 32, 33, 36, 41, 42, 43, 44, 45, 47 with 26 and 46 missing.

Even thought this is a dermatological pathology, clinicians could be consulted given that some acquired causes may be initially observed by this specialist. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. No other cutaneous lesion or abnormality of hair, nails or sweating was seen.


Clinical description HMS presents with severe and extensive skin manifestations. The primary teeth do aplmoplantar resorb but are shed with their roots prior to the permanent teeth erupting.

Hiperqueratosis palmoplantar asociada a losartán | Actas Dermo-Sifiliográficas (English Edition)

Health care resources for this disease Expert centres Diagnostic tests 6 Patient organisations 25 Orphan drug s 0.

Newer treatment modalities reported to be beneficial for both dental and dermatological lesions of PLS hiperqueratsois oral retinoids such as acitretin, etretinate and isotretinoin. A peculiar deformity of the fingers tapered, pointed phalangeal ends and a claw-like volar curve is typical.

July – September Pages e1-e20 Pages Treatment of Papillon- Lefevre Syndrome periodontitis.

This case is relevant because its clinical manifestations were rare and severe. We describe a severe case of dermatophytosis associated with exfoliative erythroderma, substantial palmoplantar keratoderma, onychodystrophy affecting all nails, diffuse non-scarring alopecia and tissue fungal invasion by Trichophyton tonsuranswhich led us to the diagnosis of AIDS. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact.

General physical examination revealed bilateral yellow coloured hyperkeratotic areas on the soles and to a lesser extent in the palms Fig.

Subscribe to our Newsletter. Preventive Periodontal Regimen in Papillon-Lefevre syndrome.