J Reprod Med. Sep;47(9) Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. Heller DS (1). Case Report. Hidradenitis Suppurativa: The Third Cause of Vulva Carcinoma. Ineke Janse1*, Gilles Diercks1,2, Jan Doff2, Marian Mourits3 and. Vulvar Hidradenitis Suppurativa: Is the Mass. Malignant? Siew-Fei Ngu, MBBS;1 Mandy M. Y. Chu, MBBS;1 Philip P. C. Ip, MBChB;2. Hextan Y. S. Ngan, MD1.

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Male patients with prolonged HS in extra-axillary areas are especially at risk of this complication. HS rarely occurs in hidradeniis locations in women, but rather in the groin or the chest [4]. Squamous cell carcinoma arising in hidradenitis suppurativa. MRI of the pelvis revealed diffuse, nodular skin thickening along the pelvic folds, up to 2.

Vu,var the affected skin area is small enough, it may be possible to surgically remove the entire area, which will cure the disease.

Other comorbidities included well controlled hypertension. Due to bacterial infection around apocrine glands of axilla, occasionally perineum or vulva Usually due to anaerobes, which cause an offensive smell Staphylococcus aureusStrep Viridans and E. HS is made worse by male hormone testosterone. The sentinel lymph nodes were free of disease. Discussion Our case highlights a rare consequence of long-standing poorly controlled hidradenitis suppurativa: Treatment of hidradenitis suppurativa with biologic medications.


A retrospective review of the histology of resections for vulvar HS was performed, and a battery of immunohistochemical stains was performed.

Early recognition is important where the prognosis of vulvar cancer is associated with lymph node metastases in the groin and tumor size [5]. This ultimately led to better wound healing despite concomitant superimposed infection.

SCC is a rare but severe complication of HS. Journal List Gynecol Oncol Rep v.

Hidradenitis Suppurativa: The Third Cause of Vulva Carcinoma

The patient continues to follow up with plastic surgery and the gynecologic oncology team. HS cannot usually be cured, but it can often be successfully kept under control. In addition, prior to surgical intervention, every effort should be made to optimize surgical outcomes and wound healing, including a multi-disciplinary approach including plastic surgery and dermatology consultation. What problems does it cause?

First-line treatment is normally a long-term oral tetracycline antibiotic such as minomycin or doxycycline. Skin inflammatory nontumor Infectious disorders Hidradenitis suppurativa Author: HS often runs in families. After these lesions heal, they often leave scars.

In this obese patient undergoing vulvar reconstruction with superimposed vulgar suppurativa, the postoperative course was further complicated by surgical site infection requiring multiple debridement procedures and prolonged courses of IV antibiotics Vancomycin, Piperacillin, Tazobactam, Ceftrizone, Flagyl with twice daily dressing changes with Dakins solution Image 3.

Eccrine glands accounted for the majority of glands in all cases. Chronic hidradenitis suppurativa; Sclerosus vulvae; Vulvar cancer.


Close follow-up and repeated skin biopsies should be performed in those with suspected malignancy. Although HS is not caused by an infection, tetracycline antibiotics improve it by a different type of action. GCDFP is a reliable marker for both apocrine differentiation and the dark cells of eccrine glands.

In early stages, approaches to treatment include non-pharmacologic methods such as avoidance of skin trauma, hygiene, smoking cessation and weight management.

HMB was negative in all cases. Women do not have as much of this as men, however they do have some and it is androgen that affects HS.

Images hosted on other servers: If you are taking the oral contraceptive pill, it can be very helpful to change to one that contains an anti-male progesterone hormone.

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HS is a lifelong condition. Please review our privacy policy. Case Report Hidradenitis Suppurativa: Status post radical hemivulvectomy creating a large defect that required intervention by plastic surgery. CD15 also was reliable for apocrine differentiation.

Additionally, the patient had a 3. Evidence of follicular obstruction was present in 11 of 13 cases.

However, tests for infection are usually negative, antibiotics do not help, and the lumps often come back after surgery.